Evaluation of a computing and engineering outreach program for girls in grades 8–10

An outreach program of workshops and guided group activities for New Hampshire\u27s eighth, ninth and tenth grade girls was offered to stimulate the girls\u27 interest in computing and engineering coursework and careers. Attitude changes before and after participation were measured using a survey instrument adapted from one developed by the Georgia Tech\u27s Institute for Computing and Education. Eight attitudinal themes were surveyed. With suitable adjustments for simultaneous testing of multiple hypotheses, statistically significant changes with moderate effect sizes were detected for three of the themes: enjoyment of technology-related activities, motivation to succeed in technical problem solving, and intention to persist in computing and engineering courses and careers

RISK AND UNCERTAINTY (UTILITY, DECISION)

The conventional theory of decision making under risk relies on axioms that reflect assumptions about people\u27s subjective attitudes towards wealth. The assumptions are unverifiable, and the axioms are too restrictive. They forbid some decision rules that a plausibly rational decision maker ( DM ) could find useful. A new method, at once less restrictive and less dependent upon subjective assumptions, motivates expected utility techniques by assuming that a DM wishes to place an upper limit on the probability of ruin. All bounded-above, increasing functions defined over a suitable domain can serve as utility functions. Now, DM can evaluate lotteries according to their buying prices, useful if one plans to withdraw capital from risk. DM can rigorously distinguish once in a lifetime lotteries from ordinary gambles; that\u27s helpful when facing Allais\u27 problem. Also, DM can exploit partial knowledge of state probabilities without choosing arbitrary point estimates for all uncertain odds. That helps to resolve problems that combine elements of both risk and uncertainty, like Ellsberg\u27s. The new method allows DM to do everything permitted under the old axioms, and more besides, with fewer and less ambitious assumptions

Representative Names of Computing Degree Programs Worldwide

Through the auspices of ACM and with support from the IEEE Computer Society, a task group charged to prepare the IT2017 report conducted an online international survey of computing faculty members about their undergraduate degree programs in computing. The purpose of this survey was to clarify the breadth of and disparities in nomenclature used by diverse communities in the computing field, where a word or phrase can mean different things in different computing communities. This paper examines the English-language words and phrases used to name the computing programs of almost six hundred survey respondents, and the countries in which those names are used. Over eight hundred program names analysed in this paper reveal six program names that together account for more than half of all program names. The paper goes on to consider possible correspondence between reported program names and the five areas of computing identified by the ACM. Names such as computer science and information technology appear to dominate, but with different meanings, while the names of other computing disciplines show clear geographic preferences. Convergence towards a very small number of highly representative program names in computing education worldwide might be deceptive. The paper calls for further examination and international collaborations to align program names with program curriculum content

Exposure to a Nonionic Surfactant Induces a Response Akin to Heat-Shock Apoptosis in Intestinal Epithelial Cells: Implications for Excipients Safety

© 2019 American Chemical Society. Amphipathic, nonionic, surfactants are widely used in pharmaceutical, food, and agricultural industry to enhance product features; as pharmaceutical excipients, they are also aimed at increasing cell membrane permeability and consequently improving oral drugs absorption. Here, we report on the concentration- and time-dependent succession of events occurring throughout and subsequent exposure of Caco-2 epithelium to a "typical" nonionic surfactant (Kolliphor HS15) to provide a molecular explanation for nonionic surfactant cytotoxicity. The study shows that the conditions of surfactant exposure, which increase plasma membrane fluidity and permeability, produced rapid (within 5 min) redox and mitochondrial effects. Apoptosis was triggered early during exposure (within 10 min) and relied upon an initial mitochondrial membrane hyperpolarization (5-10 min) as a crucial step, leading to its subsequent depolarization and caspase-3/7 activation (60 min). The apoptotic pathway appears to be triggered prior to substantial surfactant-induced membrane damage (observed ≥60 min). We hence propose that the cellular response to the model nonionic surfactant is triggered via surfactant-induced increase in plasma membrane fluidity, a phenomenon akin to the stress response to membrane fluidization induced by heat shock, and consequent apoptosis. Therefore, the fluidization effect that confers surfactants the ability to enhance drug permeability may also be intrinsically linked to the propagation of their cytotoxicity. The reported observations have important implications for the safety of a multitude of nonionic surfactants used in drug delivery formulations and to other permeability enhancing compounds with similar plasma membrane fluidizing mechanisms

Long-Term Green Renovations for the Printer’s Building of Worcester, Massachusetts

The Worcester Printer\u27s Building was built in 1923 as a printing and binding facility. It was originally known for its industrial efficiency which it has lost over the past century. To revitalize the Printer\u27s Building, the project goal was to determine the feasibility of implementing long-term green renovations. The first objective was to analyze and build upon the previously conducted IQP that focused on short-term modifications. Following the analysis, we determined which green technologies were applicable to the building. After identifying these technologies, the final objective was to provide a three and five year feasibility/action plan. With these objectives completed we were able to make recommendations for the Printer\u27s Building in its pursuit of becoming a sustainable facility

Understanding Policy Change in Developing Countries: The Spheres of Influence Framework

National policy reform is a prerequisite for improved stewardship of the global environment and figures prominently among the goals of international environmental diplomacy and transnational advocacy campaigns. Yet research on global environmental politics has proceeded absent models of policy change in developing countries, where most of the planet\u27s people, land, and biological diversity are found. In this article I present a theoretical framework to explain the domestic responses of developing countries to global environmental concerns. Drawing on research in Costa Rica and Bolivia, I situate the impact of global environmentalism in the context of complex, decades-long domestic struggles to create effective institutions. When international outcomes depend on protracted reforms in nations that are sovereign yet poor, policy change is driven by actors who successfully pair international resources (technical, financial, and ideational) with the domestic political resources needed to see through major policy innovations

Porous silicon bulk acoustic wave resonator with integrated transducer

We report that porous silicon acoustic Bragg reflectors and AlN-based transducers can be successfully combined and processed in a commercial solidly mounted resonator production line. The resulting device takes advantage of the unique acoustic properties of porous silicon in order to form a monolithically integrated bulk acoustic wave resonator

Hospital Mortality - a neglected but rich source of information supporting the transition to higher quality health systems in low and middle income countries.

BACKGROUND: There is increasing focus on the strength of primary health care systems in low and middle-income countries (LMIC). There are important roles for higher quality district hospital care within these systems. These hospitals are also sources of information of considerable importance to health systems, but this role, as with the wider roles of district hospitals, has been neglected. KEY MESSAGES: As we make efforts to develop higher quality health systems in LMIC we highlight the critical importance of district hospitals focusing here on how data on hospital mortality offers value: i) in understanding disease burden; ii) as part of surveillance and impact monitoring; iii) as an entry point to exploring system failures; and iv) as a lens to examine variability in health system performance and possibly as a measure of health system quality in its own right. However, attention needs paying to improving data quality by addressing reporting gaps and cause of death reporting. Ideally enabling the collection of basic, standardised patient level data might support at least simple case-mix and case-severity adjustment helping us understand variation. Better mortality data could support impact evaluation, benchmarking, exploration of links between health system inputs and outcomes and critical scrutiny of geographic variation in quality and outcomes of care. Improved hospital information is a neglected but broadly valuable public good. CONCLUSION: Accurate, complete and timely hospital mortality reporting is a key attribute of a functioning health system. It can support countries' efforts to transition to higher quality health systems in LMIC enabling national and local advocacy, accountability and action